Endocrine Abstracts

Infertility affects milions of couples worldwide. Determining the exact cause represents a real challenge and may require a complex work-up.Objective: To asses the main etiological factors of female infertility and the best treatment.Methods: Retrospective study which included 150 women diagnosed with infertility in a Romanian tertiary center. The median age was 30.5 years (20–41), 65.3% (n=98) of the patients were di...

Acromegaly is a rare endocrine disorder, caused by hypersecretion of growth hormone. Cardiovascular and metabolic complications reduce life expectancy. Early carbohydrate metabolism disorders and diabetes mellitus are frequently associated with acromegaly.Objective: The objective of this study was to evaluate the glycemic profile and cardiovascular complications in acromegaly.Methods: We performed a retrospective study. We included...

Objective: Acromegaly is frequently associated with thyroid diseases. In this study we evaluated the incidence, morphology of the thyroid and the influence of surgery, iradiation and medical therapy used in acromegaly on thyroid function.Methods: We evaluated 20 patients diagnosed with acromegaly using thyroid ultrasonography and measurement of IGF1, GH, TSH, free T4. 65% of the patients had active disease and were under medical therapy.<p class="abs...

Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology ‘C. I. Parhon’ showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by ...

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

Introduction: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor derived from C cells that is responsible for approximately 5% of the gland malignancies, most of them occuring sporadically. Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic factor. Surgery is the only curative therapy while other chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostat...

Introduction: There is evidence that SARS-COV-2 infection can result in development of endocrine disturbances. Expression of the angiotensin-converting enzyme 2, which is postulated to be at the center of the pathogenesis of COVID-19, has been reported in various endocrine tissues.Case Series: We retrospectively analyzed 12 patients with recent history of SARS-COV-2 infection: 5 cases with subacute thyroiditis (SAT), 2 cases with Graves’ disease, 2 ...

Introduction: Pituitary tumours may interfere with fertility and pregnancy may be uncommon in these cases, but some patients can conceive spontaneous. Also in pregnancy, due to the physiologic changes of the pituitary gland, gradual volume increase and cellular hyperplasia that target hormonal secretion, the evaluation of the pituitary function is very complex.Clinical cases: We present 5 cases of female patients (24 – 35 years old) that were diagn...

Background: Acromegaly is a rare disorder caused by hypersecretion of growth-hormone (GH) and insulin-like growth factor (IGF-1), the underlying lesion being most frequently a pituitary adenoma. This disease is associated with a higher risk of malignancy. We describe the clinical and biochemical particularities in a series of patients with acromegaly and papillary thyroid carcinoma (PTC).Case study: Out of 311 acromegalic patients, five cases that associ...

Introduction: Pituitary neuroendocrine tumors (PitNET) are characterized by a heterogenous behavior. The immunohistochemical (IHC) staining of anterior pituitary hormones, along with that of pituitary transcription factors and with the clinical and biochemical characteristics of the patients can be integrated in a risk stratification system, which helps the therapeutic management.Material and Methods: We analyzed 37 patients with confirmed diagnosis of a...